Cargando…

The mTORC1-4E-BP-eIF4E axis controls de novo Bcl6 protein synthesis in T cells and systemic autoimmunity

Post-transcriptional modifications can control protein abundance, but the extent to which these alterations contribute to the expression of T helper (T(H)) lineage-defining factors is unknown. Tight regulation of Bcl6 expression, an essential transcription factor for T follicular helper (T(FH)) cell...

Descripción completa

Detalles Bibliográficos
Autores principales:	Yi, Woelsung, Gupta, Sanjay, Ricker, Edd, Manni, Michela, Jessberger, Rolf, Chinenov, Yurii, Molina, Henrik, Pernis, Alessandra B.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5557982/ https://www.ncbi.nlm.nih.gov/pubmed/28811467 http://dx.doi.org/10.1038/s41467-017-00348-3

Ejemplares similares

Rapamycin-insensitive mTORC1 activity controls eIF4E:4E-BP1 binding
por: Livingstone, Mark, et al.
Publicado: (2012)

4E-BP restrains eIF4E phosphorylation
por: Müller, David, et al.
Publicado: (2013)

Regulation of Age-associated B cells by IRF5 in systemic autoimmunity
por: Manni, Michela, et al.
Publicado: (2018)

mTORC1 signalling and eIF4E/4E-BP1 translation initiation factor stoichiometry influence recombinant protein productivity from GS-CHOK1 cells
por: Jossé, Lyne, et al.
Publicado: (2016)

The RhoA-ROCK pathway in the regulation of T and B cell responses
por: Ricker, Edd, et al.
Publicado: (2016)

mTORC1 and CK2 coordinate ternary and eIF4F complex assembly
por: Gandin, Valentina, et al.
Publicado: (2016)

Interplay between SERCA, 4E-BP, and eIF4E in the Drosophila heart
por: Santalla, Manuela, et al.
Publicado: (2022)

Inhibition of mTORC1 Enhances the Translation of Chikungunya Proteins via the Activation of the MnK/eIF4E Pathway
por: Joubert, Pierre-Emmanuel, et al.
Publicado: (2015)

Dendritic eIF4E-binding Protein 1 (eIF4E-BP1) mRNA Is Upregulated by Neuronal Activation
por: Moon, Il Soo, et al.
Publicado: (2012)

mTOR inhibitor efficacy is determined by the eIF4E/4E-BP ratio
por: Alain, Tommy, et al.
Publicado: (2012)

Translation control during prolonged mTORC1 inhibition mediated by 4E-BP3
por: Tsukumo, Yoshinori, et al.
Publicado: (2016)

Activation of eIF4E‐binding‐protein‐1 rescues mTORC1‐induced sarcopenia by expanding lysosomal degradation capacity
por: Crombie, Elisa M., et al.
Publicado: (2022)

Synergistic activation of eIF4A by eIF4B and eIF4G
por: Nielsen, Klaus H., et al.
Publicado: (2011)

Regulatory effects of a Mnk2-eIF4E feedback loop during mTORC1 targeting of human medulloblastoma cells
por: Eckerdt, Frank, et al.
Publicado: (2014)

Repair of Isoaspartate Formation Modulates the Interaction of Deamidated 4E-BP2 with mTORC1 in Brain
por: Bidinosti, Michael, et al.
Publicado: (2010)

Suppression of Hypoxia-Inducible Factor 1α (HIF-1α) by Tirapazamine Is Dependent on eIF2α Phosphorylation Rather Than the mTORC1/4E-BP1 Pathway
por: Zhang, Jun, et al.
Publicado: (2010)

The translational repressor 4E-BP called to order by eIF4E: new structural insights by SAXS
por: Gosselin, Pauline, et al.
Publicado: (2011)

Dissociation of eIF4E-Binding Protein 2 (4E-BP2) from eIF4E Independent of Thr(37)/Thr(46) Phosphorylation in the Ischemic Stress Response
por: Ayuso, María I., et al.
Publicado: (2015)

The mTORC1/4E-BP1 axis represents a critical signaling node during fibrogenesis
por: Woodcock, Hannah V., et al.
Publicado: (2019)

The 4E-BP Caf20p Mediates Both eIF4E-Dependent and Independent Repression of Translation
por: Castelli, Lydia M., et al.
Publicado: (2015)

Evolutionary changes in the Leishmania eIF4F complex involve variations in the eIF4E–eIF4G interactions
por: Yoffe, Yael, et al.
Publicado: (2009)

eIF4B, eIF4G and RNA regulate eIF4A activity in translation initiation by modulating the eIF4A conformational cycle
por: Harms, Ulf, et al.
Publicado: (2014)

Borneol promotes apoptosis of Human Glioma Cells through regulating HIF-1a expression via mTORC1/eIF4E pathway
por: Wang, Zeng, et al.
Publicado: (2020)

The mTORC1/eIF4E/HIF-1α Pathway Mediates Glycolysis to Support Brain Hypoxia Resistance in the Gansu Zokor, Eospalax cansus
por: Lin, Jinyan, et al.
Publicado: (2021)

Selectivity for eIF4E
por: LeBrasseur, Nicole
Publicado: (2005)

Loss-of-Function Analysis Reveals Distinct Requirements of the Translation Initiation Factors eIF4E, eIF4E-3, eIF4G and eIF4G2 in Drosophila Spermatogenesis
por: Ghosh, Sanjay, et al.
Publicado: (2015)

Discordant regulation of eIF2 kinase GCN2 and mTORC1 during nutrient stress
por: Misra, Jagannath, et al.
Publicado: (2021)

Stabilization of p21 by mTORC1/4E-BP1 predicts clinical outcome of head and neck cancers
por: Llanos, Susana, et al.
Publicado: (2016)

The mTORC1 Effectors S6K1 and 4E-BP Play Different Roles in CNS Axon Regeneration
por: Yang, Liu, et al.
Publicado: (2014)

CDK12 phosphorylates 4E-BP1 to enable mTORC1-dependent translation and mitotic genome stability
por: Choi, Seung H., et al.
Publicado: (2019)

Human eukaryotic initiation factor 4E (eIF4E) and the nucleotide-bound state of eIF4A regulate eIF4F binding to RNA
por: Izidoro, Mario Servulo, et al.
Publicado: (2022)

Borneol promotes apoptosis of Human Glioma Cells through regulating HIF-1a expression via mTORC1/eIF4E pathway: Erratum
por: Wang, Zeng, et al.
Publicado: (2022)

eIF4A inactivates TORC1 in response to amino acid starvation
por: Tsokanos, Foivos‐Filippos, et al.
Publicado: (2016)

Signalling to eIF4E in cancer
por: Siddiqui, Nadeem, et al.
Publicado: (2015)

Constitutive phosphorylation of the mTORC2/Akt/4E-BP1 pathway in newly derived canine hemangiosarcoma cell lines
por: Murai, Atsuko, et al.
Publicado: (2012)

Author Correction: The mTORC1/4E-BP1 axis represents a critical signaling node during fibrogenesis
por: Woodcock, Hannah V., et al.
Publicado: (2020)

Functional Translatome Proteomics Reveal Converging and Dose-Dependent Regulation by mTORC1 and eIF2α
por: Klann, Kevin, et al.
Publicado: (2020)

TRIBE editing reveals specific mRNA targets of eIF4E-BP in Drosophila and in mammals
por: Jin, Hua, et al.
Publicado: (2020)

Mitosis-related phosphorylation of the eukaryotic translation suppressor 4E-BP1 and its interaction with eukaryotic translation initiation factor 4E (eIF4E)
por: Sun, Rui, et al.
Publicado: (2019)

The Initiation Factors eIF2, eIF2A, eIF2D, eIF4A, and eIF4G Are Not Involved in Translation Driven by Hepatitis C Virus IRES in Human Cells
por: González-Almela, Esther, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_4kf567sfq7ie3km5c6jq0ls8sb