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Rapid and accurate in silico solubility screening of a monoclonal antibody library

Antibodies represent essential tools in research and diagnostics and are rapidly growing in importance as therapeutics. Commonly used methods to obtain novel antibodies typically yield several candidates capable of engaging a given target. The development steps that follow, however, are usually perf...

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Detalles Bibliográficos
Autores principales: Sormanni, Pietro, Amery, Leanne, Ekizoglou, Sofia, Vendruscolo, Michele, Popovic, Bojana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5558012/
https://www.ncbi.nlm.nih.gov/pubmed/28811609
http://dx.doi.org/10.1038/s41598-017-07800-w