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Rapid and accurate in silico solubility screening of a monoclonal antibody library
Antibodies represent essential tools in research and diagnostics and are rapidly growing in importance as therapeutics. Commonly used methods to obtain novel antibodies typically yield several candidates capable of engaging a given target. The development steps that follow, however, are usually perf...
Autores principales: | Sormanni, Pietro, Amery, Leanne, Ekizoglou, Sofia, Vendruscolo, Michele, Popovic, Bojana |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2017
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5558012/ https://www.ncbi.nlm.nih.gov/pubmed/28811609 http://dx.doi.org/10.1038/s41598-017-07800-w |
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