Modeling of RAS complexes supports roles in cancer for less studied partners

BACKGROUND: RAS protein interactions have predominantly been studied in the context of the RAF and PI3kinase oncogenic pathways. Structural modeling and X-ray crystallography have demonstrated that RAS isoforms bind to canonical downstream effector proteins in these pathways using the highly conserv...

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Detalles Bibliográficos
Autores principales: Engin, H. Billur, Carlin, Daniel, Pratt, Dexter, Carter, Hannah
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5558186/
https://www.ncbi.nlm.nih.gov/pubmed/28815022
http://dx.doi.org/10.1186/s13628-017-0037-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5558186/
https://www.ncbi.nlm.nih.gov/pubmed/28815022
http://dx.doi.org/10.1186/s13628-017-0037-6

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