UV radiation promotes melanoma dissemination mediated by the sequential reaction axis of cathepsins–TGF-β1–FAP-α

BACKGROUND: Ultraviolet radiation (UVR) is the major risk factor for development of malignant melanoma. Fibroblast activation protein (FAP)-α is a serine protease expressed on the surface of activated fibroblasts, promoting tumour invasion through extracellular matrix (ECM) degradation. The signalli...

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Detalles Bibliográficos
Autores principales: Wäster, Petra, Orfanidis, Kyriakos, Eriksson, Ida, Rosdahl, Inger, Seifert, Oliver, Öllinger, Karin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Molecular Diagnostics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5558678/
https://www.ncbi.nlm.nih.gov/pubmed/28697174
http://dx.doi.org/10.1038/bjc.2017.182

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5558678/
https://www.ncbi.nlm.nih.gov/pubmed/28697174
http://dx.doi.org/10.1038/bjc.2017.182

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