Exploiting the Ref-1-APE1 node in cancer signaling and other diseases: from bench to clinic

Reduction-oxidation factor 1-apurinic/apyrimidinic endonuclease (Ref-1/APE1) is a critical node in tumor cells, both as a redox regulator of transcription factor activation and as part of the DNA damage response. As a redox signaling protein, Ref-1/APE1 enhances the transcriptional activity of STAT3...

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Detalles Bibliográficos
Autores principales: Shah, Fenil, Logsdon, Derek, Messmann, Richard A., Fehrenbacher, Jill C., Fishel, Melissa L., Kelley, Mark R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5558897/
https://www.ncbi.nlm.nih.gov/pubmed/28825044
http://dx.doi.org/10.1038/s41698-017-0023-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5558897/
https://www.ncbi.nlm.nih.gov/pubmed/28825044
http://dx.doi.org/10.1038/s41698-017-0023-0

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