Identification of an optimized 2′-O-methylated trinucleotide RNA motif inhibiting Toll-like receptors 7 and 8

Bacterial RNA serves an important function as activator of the innate immune system. In humans bacterial RNA is sensed by the endosomal receptors TLR7 and TLR8. Differences in the posttranscriptional modification profile of prokaryotic when compared with eukaryotic RNA allow innate immune cells to d...

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Detalles Bibliográficos
Autores principales: Schmitt, Felix C.F., Freund, Isabel, Weigand, Markus A., Helm, Mark, Dalpke, Alexander H., Eigenbrod, Tatjana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2017
Materias:
Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5558904/
https://www.ncbi.nlm.nih.gov/pubmed/28576825
http://dx.doi.org/10.1261/rna.061952.117

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5558904/
https://www.ncbi.nlm.nih.gov/pubmed/28576825
http://dx.doi.org/10.1261/rna.061952.117

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