Impaired DNA replication derepresses chromatin and generates a transgenerationally inherited epigenetic memory

Impaired DNA replication is a hallmark of cancer and a cause of genomic instability. We report that, in addition to causing genetic change, impaired DNA replication during embryonic development can have major epigenetic consequences for a genome. In a genome-wide screen, we identified impaired DNA r...

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Detalles Bibliográficos
Autores principales: Klosin, Adam, Reis, Kadri, Hidalgo-Carcedo, Cristina, Casas, Eduard, Vavouri, Tanya, Lehner, Ben
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2017
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5559210/
https://www.ncbi.nlm.nih.gov/pubmed/28835928
http://dx.doi.org/10.1126/sciadv.1701143

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5559210/
https://www.ncbi.nlm.nih.gov/pubmed/28835928
http://dx.doi.org/10.1126/sciadv.1701143

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