Cargando…
Impaired DNA replication derepresses chromatin and generates a transgenerationally inherited epigenetic memory
Impaired DNA replication is a hallmark of cancer and a cause of genomic instability. We report that, in addition to causing genetic change, impaired DNA replication during embryonic development can have major epigenetic consequences for a genome. In a genome-wide screen, we identified impaired DNA r...
| Autores principales: | , , , , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Association for the Advancement of Science
2017
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5559210/ https://www.ncbi.nlm.nih.gov/pubmed/28835928 http://dx.doi.org/10.1126/sciadv.1701143 |