Identification of Novel Non-secosteroidal Vitamin D Receptor Agonists with Potent Cardioprotective Effects and devoid of Hypercalcemia

Vitamin D regulates many biological processes, but its clinical utility is limited by its hypercalcemic effect. Using a virtual screening platform to search novel chemical probes that activate the vitamin D signaling, we report discovery of novel non-steroidal small-molecule compounds that activate...

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Detalles Bibliográficos
Autores principales: Khedkar, Santosh A., Samad, Mohammed A., Choudhury, Sangita, Lee, Ji Yoo, Zhang, Dongsheng, Thadhani, Ravi I., Karumanchi, S. Ananth, Rigby, Alan C., Kang, Peter M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5559458/
https://www.ncbi.nlm.nih.gov/pubmed/28814738
http://dx.doi.org/10.1038/s41598-017-08670-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5559458/
https://www.ncbi.nlm.nih.gov/pubmed/28814738
http://dx.doi.org/10.1038/s41598-017-08670-y

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