Spatial genomic heterogeneity in multiple myeloma revealed by multi-region sequencing

In multiple myeloma malignant plasma cells expand within the bone marrow. Since this site is well-perfused, a rapid dissemination of “fitter” clones may be anticipated. However, an imbalanced distribution of multiple myeloma is frequently observed in medical imaging. Here, we perform multi-region se...

Descripción completa

Detalles Bibliográficos
Autores principales: Rasche, L., Chavan, S. S., Stephens, O. W., Patel, P. H., Tytarenko, R., Ashby, C., Bauer, M., Stein, C., Deshpande, S., Wardell, C., Buzder, T., Molnar, G., Zangari, M., van Rhee, F., Thanendrarajan, S., Schinke, C., Epstein, J., Davies, F. E., Walker, B. A., Meissner, T., Barlogie, B., Morgan, G. J., Weinhold, N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5559527/
https://www.ncbi.nlm.nih.gov/pubmed/28814763
http://dx.doi.org/10.1038/s41467-017-00296-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5559527/
https://www.ncbi.nlm.nih.gov/pubmed/28814763
http://dx.doi.org/10.1038/s41467-017-00296-y

Ejemplares similares