Oncofetal HMGA2 effectively curbs unconstrained (+) and (−) DNA supercoiling

HMGA2 belongs to the family of the high mobility group (HMG) proteins. It binds DNA via three AT-hook domains to the minor groove of adenine-thymine (AT) rich DNA. Recently, a new function of HMGA2 as a replication fork chaperone that protects stem and cancer cells from replication fork collapse ind...

Descripción completa

Detalles Bibliográficos
Autores principales: Zhao, Xiaodan, Peter, Sabrina, Dröge, Peter, Yan, Jie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5559611/
https://www.ncbi.nlm.nih.gov/pubmed/28814752
http://dx.doi.org/10.1038/s41598-017-09104-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5559611/
https://www.ncbi.nlm.nih.gov/pubmed/28814752
http://dx.doi.org/10.1038/s41598-017-09104-5

Ejemplares similares