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Oncofetal HMGA2 effectively curbs unconstrained (+) and (−) DNA supercoiling
HMGA2 belongs to the family of the high mobility group (HMG) proteins. It binds DNA via three AT-hook domains to the minor groove of adenine-thymine (AT) rich DNA. Recently, a new function of HMGA2 as a replication fork chaperone that protects stem and cancer cells from replication fork collapse ind...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2017
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5559611/ https://www.ncbi.nlm.nih.gov/pubmed/28814752 http://dx.doi.org/10.1038/s41598-017-09104-5 |