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Rapamycin Prevents cyclophosphamide-induced Over-activation of Primordial Follicle pool through PI3K/Akt/mTOR Signaling Pathway in vivo

BACKGROUND: Primordial follicular depletion has thought to be a common adverse effect of chemotherapy especially for female of reproductive age. The study aimed to evaluate the protective effect of rapamycin on the primordial follicles and its potential mechanism for patients receiving chemotherapy....

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Detalles Bibliográficos
Autores principales: Zhou, Linyan, Xie, Yanqiu, Li, Song, Liang, Yihua, Qiu, Qi, Lin, Haiyan, Zhang, Qingxue
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5559863/
https://www.ncbi.nlm.nih.gov/pubmed/28814333
http://dx.doi.org/10.1186/s13048-017-0350-3