(CCUG)(n) RNA toxicity in a Drosophila model of myotonic dystrophy type 2 (DM2) activates apoptosis

The myotonic dystrophies are prototypic toxic RNA gain-of-function diseases. Myotonic dystrophy type 1 (DM1) and type 2 (DM2) are caused by different unstable, noncoding microsatellite repeat expansions – (CTG)(DM1) in DMPK and (CCTG)(DM2) in CNBP. Although transcription of mutant repeats into (CUG)...

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Detalles Bibliográficos
Autores principales: Yenigun, Vildan Betul, Sirito, Mario, Amcheslavky, Alla, Czernuszewicz, Tomek, Colonques-Bellmunt, Jordi, García-Alcover, Irma, Wojciechowska, Marzena, Bolduc, Clare, Chen, Zhihong, López Castel, Arturo, Krahe, Ralf, Bergmann, Andreas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists Ltd 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5560059/
https://www.ncbi.nlm.nih.gov/pubmed/28623239
http://dx.doi.org/10.1242/dmm.026179

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5560059/
https://www.ncbi.nlm.nih.gov/pubmed/28623239
http://dx.doi.org/10.1242/dmm.026179

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