Phosphorylation of HIV Tat by PKR increases interaction with TAR RNA and enhances transcription

BACKGROUND: The interferon (IFN)-induced, dsRNA-dependent serine/threonine protein kinase, PKR, plays a key regulatory role in the IFN-mediated anti-viral response by blocking translation in the infected cell by phosphorylating the alpha subunit of elongation factor 2 (eIF2). The human immunodeficie...

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Detalles Bibliográficos
Autores principales: Endo-Munoz, Liliana, Warby, Tammra, Harrich, David, McMillan, Nigel AJ
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2005
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC556014/
https://www.ncbi.nlm.nih.gov/pubmed/15737233
http://dx.doi.org/10.1186/1743-422X-2-17

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC556014/
https://www.ncbi.nlm.nih.gov/pubmed/15737233
http://dx.doi.org/10.1186/1743-422X-2-17

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