Combining Chk1/2 Inhibition with Cetuximab and Radiation Enhances In Vitro and In Vivo Cytotoxicity in Head and Neck Squamous Cell Carcinoma

EGFR inhibition and radiotherapy are potent inducers of DNA damage. Checkpoint kinases 1 and 2 (Chk1/2) are critical regulators of the DNA-damage response, controlling cell-cycle checkpoints that may permit recovery from therapy-associated genomic stress. We hypothesized that Chk1/2 inhibition (CHKi...

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Detalles Bibliográficos
Autores principales: Zeng, Ling, Beggs, Reena R., Cooper, Tiffiny S., N.Weaver, Alice, S.Yang, Eddy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5560482/
https://www.ncbi.nlm.nih.gov/pubmed/28138028
http://dx.doi.org/10.1158/1535-7163.MCT-16-0352

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5560482/
https://www.ncbi.nlm.nih.gov/pubmed/28138028
http://dx.doi.org/10.1158/1535-7163.MCT-16-0352

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