Identification of interleukin-1 beta as a key mediator in the upregulation of Cav3.2–USP5 interactions in the pain pathway

We recently reported that nerve injury or peripheral inflammation triggers an upregulation of the deubiquitinase, USP5 in mouse dorsal root ganglion and spinal dorsal horn. This leads to dysregulated ubiquitination of Cav3.2 T-type calcium channels, thus increasing Cav3.2 channel plasma membrane exp...

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Detalles Bibliográficos
Autores principales: Stemkowski, Patrick L, Garcia-Caballero, Agustin, Gadotti, Vinicius M, M’Dahoma, Said, Chen, Lina, Souza, Ivana A, Zamponi, Gerald W
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2017
Materias:
Short Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5560507/
https://www.ncbi.nlm.nih.gov/pubmed/28741432
http://dx.doi.org/10.1177/1744806917724698

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5560507/
https://www.ncbi.nlm.nih.gov/pubmed/28741432
http://dx.doi.org/10.1177/1744806917724698

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