TPL-2 restricts Ccl24-dependent immunity to Heligmosomoides polygyrus

TPL-2 (COT, MAP3K8) kinase activates the MEK1/2-ERK1/2 MAPK signaling pathway in innate immune responses following TLR, TNFR1 and IL-1R stimulation. TPL-2 contributes to type-1/Th17-mediated autoimmunity and control of intracellular pathogens. We recently demonstrated TPL-2 reduces severe airway all...

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Detalles Bibliográficos
Autores principales: Kannan, Yashaswini, Entwistle, Lewis J., Pelly, Victoria S., Perez-Lloret, Jimena, Walker, Alan W., Ley, Steven C., Wilson, Mark S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5560741/
https://www.ncbi.nlm.nih.gov/pubmed/28759611
http://dx.doi.org/10.1371/journal.ppat.1006536

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5560741/
https://www.ncbi.nlm.nih.gov/pubmed/28759611
http://dx.doi.org/10.1371/journal.ppat.1006536

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