Heat-Induced Calcium Leakage Causes Mitochondrial Damage in Caenorhabditis elegans Body-Wall Muscles

Acute onset of organ failure in heatstroke is triggered by rhabdomyolysis of skeletal muscle. Here, we showed that elevated temperature increases free cytosolic Ca(2+) [Ca(2+)]f from RYR (ryanodine receptor)/UNC-68 in vivo in the muscles of an experimental model animal, the nematode Caenorhabditis e...

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Detalles Bibliográficos
Autores principales: Momma, Kenta, Homma, Takashi, Isaka, Ruri, Sudevan, Surabhi, Higashitani, Atsushi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Genetics Society of America 2017
Materias:
Investigations
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5560802/
https://www.ncbi.nlm.nih.gov/pubmed/28576866
http://dx.doi.org/10.1534/genetics.117.202747

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5560802/
https://www.ncbi.nlm.nih.gov/pubmed/28576866
http://dx.doi.org/10.1534/genetics.117.202747

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