Human cytomegalovirus escapes immune recognition by NK cells through the downregulation of B7-H6 by the viral genes US18 and US20

Human cytomegalovirus (HCMV) is a major human pathogen, causing serious diseases in immunocompromised populations and congenially infected neonates. One of the main immune cells acting against the virus are Natural Killer (NK) cells. Killing by NK cells is mediated by a small family of activating re...

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Autores principales: Charpak-Amikam, Yoav, Kubsch, Tobias, Seidel, Einat, Oiknine-Djian, Esther, Cavaletto, Noemi, Yamin, Rachel, Schmiedel, Dominik, Wolf, Dana, Gribaudo, Giorgio, Messerle, Martin, Cicin-Sain, Luka, Mandelboim, Ofer
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5561058/
https://www.ncbi.nlm.nih.gov/pubmed/28819195
http://dx.doi.org/10.1038/s41598-017-08866-2
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author Charpak-Amikam, Yoav
Kubsch, Tobias
Seidel, Einat
Oiknine-Djian, Esther
Cavaletto, Noemi
Yamin, Rachel
Schmiedel, Dominik
Wolf, Dana
Gribaudo, Giorgio
Messerle, Martin
Cicin-Sain, Luka
Mandelboim, Ofer
author_facet Charpak-Amikam, Yoav
Kubsch, Tobias
Seidel, Einat
Oiknine-Djian, Esther
Cavaletto, Noemi
Yamin, Rachel
Schmiedel, Dominik
Wolf, Dana
Gribaudo, Giorgio
Messerle, Martin
Cicin-Sain, Luka
Mandelboim, Ofer
author_sort Charpak-Amikam, Yoav
collection PubMed
description Human cytomegalovirus (HCMV) is a major human pathogen, causing serious diseases in immunocompromised populations and congenially infected neonates. One of the main immune cells acting against the virus are Natural Killer (NK) cells. Killing by NK cells is mediated by a small family of activating receptors such as NKp30 that interact with the cellular ligand B7-H6. The outcome of B7-H6-NKp30 interaction was, so far, mainly studied with regard to NK recognition and killing of tumors. Here, we demonstrated that the expression of B7-H6 is upregulated following HCMV infection and that HCMV uses two of its genes: US18 and US20, to interfere with B7-H6 surface expression, in a mechanism involving endosomal degradation, in order to evade NK cell recognition.
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spelling pubmed-55610582017-08-18 Human cytomegalovirus escapes immune recognition by NK cells through the downregulation of B7-H6 by the viral genes US18 and US20 Charpak-Amikam, Yoav Kubsch, Tobias Seidel, Einat Oiknine-Djian, Esther Cavaletto, Noemi Yamin, Rachel Schmiedel, Dominik Wolf, Dana Gribaudo, Giorgio Messerle, Martin Cicin-Sain, Luka Mandelboim, Ofer Sci Rep Article Human cytomegalovirus (HCMV) is a major human pathogen, causing serious diseases in immunocompromised populations and congenially infected neonates. One of the main immune cells acting against the virus are Natural Killer (NK) cells. Killing by NK cells is mediated by a small family of activating receptors such as NKp30 that interact with the cellular ligand B7-H6. The outcome of B7-H6-NKp30 interaction was, so far, mainly studied with regard to NK recognition and killing of tumors. Here, we demonstrated that the expression of B7-H6 is upregulated following HCMV infection and that HCMV uses two of its genes: US18 and US20, to interfere with B7-H6 surface expression, in a mechanism involving endosomal degradation, in order to evade NK cell recognition. Nature Publishing Group UK 2017-08-17 /pmc/articles/PMC5561058/ /pubmed/28819195 http://dx.doi.org/10.1038/s41598-017-08866-2 Text en © The Author(s) 2017 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Charpak-Amikam, Yoav
Kubsch, Tobias
Seidel, Einat
Oiknine-Djian, Esther
Cavaletto, Noemi
Yamin, Rachel
Schmiedel, Dominik
Wolf, Dana
Gribaudo, Giorgio
Messerle, Martin
Cicin-Sain, Luka
Mandelboim, Ofer
Human cytomegalovirus escapes immune recognition by NK cells through the downregulation of B7-H6 by the viral genes US18 and US20
title Human cytomegalovirus escapes immune recognition by NK cells through the downregulation of B7-H6 by the viral genes US18 and US20
title_full Human cytomegalovirus escapes immune recognition by NK cells through the downregulation of B7-H6 by the viral genes US18 and US20
title_fullStr Human cytomegalovirus escapes immune recognition by NK cells through the downregulation of B7-H6 by the viral genes US18 and US20
title_full_unstemmed Human cytomegalovirus escapes immune recognition by NK cells through the downregulation of B7-H6 by the viral genes US18 and US20
title_short Human cytomegalovirus escapes immune recognition by NK cells through the downregulation of B7-H6 by the viral genes US18 and US20
title_sort human cytomegalovirus escapes immune recognition by nk cells through the downregulation of b7-h6 by the viral genes us18 and us20
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5561058/
https://www.ncbi.nlm.nih.gov/pubmed/28819195
http://dx.doi.org/10.1038/s41598-017-08866-2
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