The Gαi-GIV binding interface is a druggable protein-protein interaction

Heterotrimeric G proteins are usually activated by the guanine-nucleotide exchange factor (GEF) activity of GPCRs. However, some non-receptor proteins are also GEFs. GIV (a.k.a Girdin) was the first non-receptor protein for which the GEF activity was ascribed to a well-defined protein sequence that...

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Detalles Bibliográficos
Autores principales: DiGiacomo, Vincent, de Opakua, Alain Ibáñez, Papakonstantinou, Maria P., Nguyen, Lien T., Merino, Nekane, Blanco-Canosa, Juan B., Blanco, Francisco J., Garcia-Marcos, Mikel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5561080/
https://www.ncbi.nlm.nih.gov/pubmed/28819150
http://dx.doi.org/10.1038/s41598-017-08829-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5561080/
https://www.ncbi.nlm.nih.gov/pubmed/28819150
http://dx.doi.org/10.1038/s41598-017-08829-7

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