G9a regulates breast cancer growth by modulating iron homeostasis through the repression of ferroxidase hephaestin

G9a, a H3K9 methyltransferase, shows elevated expression in many types of human cancers, particularly breast cancer. However, the tumorigenic mechanism of G9a is still far from clear. Here we report that G9a exerts its oncogenic function in breast cancer by repressing hephaestin and destruction cell...

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Detalles Bibliográficos
Autores principales: Wang, Ya-fang, Zhang, Jie, Su, Yi, Shen, Yan-yan, Jiang, Dong-xian, Hou, Ying-yong, Geng, Mei-yu, Ding, Jian, Chen, Yi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5561105/
https://www.ncbi.nlm.nih.gov/pubmed/28819251
http://dx.doi.org/10.1038/s41467-017-00350-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5561105/
https://www.ncbi.nlm.nih.gov/pubmed/28819251
http://dx.doi.org/10.1038/s41467-017-00350-9

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