Thermodynamic and Kinetic Analyses of Iron Response Element (IRE)-mRNA Binding to Iron Regulatory Protein, IRP1

Comparison of kinetic and thermodynamic properties of IRP1 (iron regulatory protein1) binding to FRT (ferritin) and ACO2 (aconitase2) IRE-RNAs, with or without Mn(2+), revealed differences specific to each IRE-RNA. Conserved among animal mRNAs, IRE-RNA structures are noncoding and bind Fe(2+) to reg...

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Detalles Bibliográficos
Autores principales: Khan, Mateen A., Walden, William E., Theil, Elizabeth C., Goss, Dixie J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5561112/
https://www.ncbi.nlm.nih.gov/pubmed/28819260
http://dx.doi.org/10.1038/s41598-017-09093-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5561112/
https://www.ncbi.nlm.nih.gov/pubmed/28819260
http://dx.doi.org/10.1038/s41598-017-09093-5

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