Cargando…

Delta inulin-based adjuvants promote the generation of polyfunctional CD4(+) T cell responses and protection against Mycobacterium tuberculosis infection

There is an urgent need for the rational design of safe and effective vaccines to protect against chronic bacterial pathogens such as Mycobacterium tuberculosis. Advax™ is a novel adjuvant based on delta inulin microparticles that enhances immunity with a minimal inflammatory profile and has entered...

Descripción completa

Detalles Bibliográficos
Autores principales:	Counoupas, Claudio, Pinto, Rachel, Nagalingam, Gayathri, Britton, Warwick J., Petrovsky, Nikolai, Triccas, James A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5561132/ https://www.ncbi.nlm.nih.gov/pubmed/28819247 http://dx.doi.org/10.1038/s41598-017-09119-y

Ejemplares similares

Intrapulmonary vaccination with delta-inulin adjuvant stimulates non-polarised chemotactic signalling and diverse cellular interaction
por: Ferrell, Kia C., et al.
Publicado: (2021)

Mycobacterium tuberculosis components expressed during chronic infection of the lung contribute to long-term control of pulmonary tuberculosis in mice
por: Counoupas, Claudio, et al.
Publicado: (2016)

Characterization of the Protective Immune Responses Conferred by Recombinant BCG Overexpressing Components of Mycobacterium tuberculosis Sec Protein Export System
por: Nisa, Annuurun, et al.
Publicado: (2022)

Mucosal immunization with a delta-inulin adjuvanted recombinant spike vaccine elicits lung-resident immune memory and protects mice against SARS-CoV-2
por: Stewart, Erica L., et al.
Publicado: (2022)

Mucosal delivery of a multistage subunit vaccine promotes development of lung-resident memory T cells and affords interleukin-17-dependent protection against pulmonary tuberculosis
por: Counoupas, Claudio, et al.
Publicado: (2020)

Immunotherapy – 2076. A controlled study of delta inulin-adjuvanted honey bee venom immunotherapy
por: Heddle, Robert, et al.
Publicado: (2013)

Synthesis and Characterization of pH-Sensitive Inulin Conjugate of Isoniazid for Monocyte-Targeted Delivery
por: Afinjuomo, Franklin, et al.
Publicado: (2019)

L-selectin-dependent and -independent homing of naïve lymphocytes through the lung draining lymph node support T cell response to pulmonary Mycobacterium tuberculosis infection
por: Daniel, Lina, et al.
Publicado: (2023)

Randomized controlled trial demonstrating the benefits of delta inulin adjuvanted immunotherapy in patients with bee venom allergy
por: Heddle, Robert, et al.
Publicado: (2019)

Adjuvant Strategies for More Effective Tuberculosis Vaccine Immunity
por: Stewart, Erica, et al.
Publicado: (2019)

Stromal structure remodeling by B lymphocytes limits T cell activation in lymph nodes of Mycobacterium tuberculosis–infected mice
por: Daniel, Lina, et al.
Publicado: (2022)

Advax™, a novel microcrystalline polysaccharide particle engineered from delta inulin, provides robust adjuvant potency together with tolerability and safety
por: Petrovsky, Nikolai, et al.
Publicado: (2015)

Advax delta inulin adjuvant overcomes immune immaturity in neonatal mice thereby allowing single–dose influenza vaccine protection
por: Honda-Okubo, Yoshikazu, et al.
Publicado: (2015)

Development of a SARS Coronavirus Vaccine from Recombinant Spike Protein Plus Delta Inulin Adjuvant
por: McPherson, Clifton, et al.
Publicado: (2015)

Novel vaccination approaches to prevent tuberculosis in children
por: Triccas, James A., et al.
Publicado: (2016)

Human Phase 1 trial of low-dose inactivated seasonal influenza vaccine formulated with Advax™ delta inulin adjuvant
por: Gordon, David L., et al.
Publicado: (2016)

Correction: Stewart et al. Adjuvant Strategies for More Effective Tuberculosis Vaccine Immunity. Microorganisms 2019, 7, 255
por: Stewart, Erica, et al.
Publicado: (2022)

Advax, a Delta Inulin Microparticle, Potentiates In-built Adjuvant Property of Co-administered Vaccines
por: Hayashi, Masayuki, et al.
Publicado: (2016)

The Secreted Lipoprotein, MPT83, of Mycobacterium tuberculosis Is Recognized during Human Tuberculosis and Stimulates Protective Immunity in Mice
por: Kao, Fan F., et al.
Publicado: (2012)

Safety and immunogenicity of a delta inulin-adjuvanted inactivated Japanese encephalitis virus vaccine in pregnant mares and foals
por: Bielefeldt-Ohmann, Helle, et al.
Publicado: (2014)

Delta Inulin Adjuvant Enhances Plasmablast Generation, Expression of Activation-Induced Cytidine Deaminase and B-Cell Affinity Maturation in Human Subjects Receiving Seasonal Influenza Vaccine
por: Li, Lei, et al.
Publicado: (2015)

Virulence Mechanisms of Mycobacterium abscessus: Current Knowledge and Implications for Vaccine Design
por: Ferrell, Kia C., et al.
Publicado: (2022)

Panblok-H1+advax H1N1/2009pdm vaccine: Insights into rapid development of a delta inulin adjuvanted recombinant pandemic influenza vaccine
por: Honda-Okubo, Yoshikazu, et al.
Publicado: (2017)

Bengamides display potent activity against drug-resistant Mycobacterium tuberculosis
por: Quan, Diana H., et al.
Publicado: (2019)

Advax Adjuvant: A Potent and Safe Immunopotentiator Composed of Delta Inulin
por: Petroski, N.
Publicado: (2017)

Advancing Adjuvants for Mycobacterium tuberculosis Therapeutics
por: Enriquez, Ana B., et al.
Publicado: (2021)

Polyfunctional CD4(+) T Cells As Targets for Tuberculosis Vaccination
por: Lewinsohn, Deborah A., et al.
Publicado: (2017)

CXCR3 Provides a Competitive Advantage for Retention of Mycobacterium tuberculosis-Specific Tissue-Resident Memory T Cells Following a Mucosal Tuberculosis Vaccine
por: Armitage, Ellis, et al.
Publicado: (2023)

Doxorubicin-Loaded Delta Inulin Conjugates for Controlled and Targeted Drug Delivery: Development, Characterization, and In Vitro Evaluation
por: Wang, Lixin, et al.
Publicado: (2019)

DNA immunization of Mycobacterium tuberculosis resuscitation-promoting factor B elicits polyfunctional CD8(+) T cell responses
por: Lee, Jino, et al.
Publicado: (2014)

Boosting BCG with recombinant influenza A virus tuberculosis vaccines increases pulmonary T cell responses but not protection against Mycobacterium tuberculosis infection
por: Muflihah, Heni, et al.
Publicado: (2021)

High-Titer Neutralizing Antibodies against the SARS-CoV-2 Delta Variant Induced by Alhydroxyquim-II-Adjuvanted Trimeric Spike Antigens
por: Counoupas, Claudio, et al.
Publicado: (2022)

Influence of Oxidation Degree on the Physicochemical Properties of Oxidized Inulin
por: Afinjuomo, Franklin, et al.
Publicado: (2020)

Immunity to Mycobacterium tuberculosis
por: Triccas, James A., et al.
Publicado: (2011)

An inactivated Vero cell-grown Japanese encephalitis vaccine formulated with Advax, a novel inulin-based adjuvant, induces protective neutralizing antibody against homologous and heterologous flaviviruses
por: Lobigs, Mario, et al.
Publicado: (2010)

Adjuvant IL-7 potentiates adoptive T cell therapy by amplifying and sustaining polyfunctional antitumor CD4+ T cells
por: Ding, Zhi-Chun, et al.
Publicado: (2017)

Evaluating Cellular Polyfunctionality with a Novel Polyfunctionality Index
por: Larsen, Martin, et al.
Publicado: (2012)

Circulating Mycobacterium tuberculosis DosR latency antigen-specific, polyfunctional, regulatory IL10(+) Th17 CD4 T-cells differentiate latent from active tuberculosis
por: Rakshit, Srabanti, et al.
Publicado: (2017)

An Adjuvanted Polyprotein HIV-1 Vaccine Induces Polyfunctional Cross-Reactive CD4(+) T Cell Responses in Seronegative Volunteers
por: Van Braeckel, Eva, et al.
Publicado: (2011)

Inulin: A New Adjuvant With Unknown Mode of Action
por: Skwarczynski, Mariusz
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_eirq6acq9ft8rjmse6iflnt3cu