Liquid–liquid phase separation of the microtubule-binding repeats of the Alzheimer-related protein Tau

The protein Tau aggregates into tangles in the brain of patients with Alzheimer’s disease. In solution, however, Tau is intrinsically disordered, highly soluble, and binds to microtubules. It is still unclear what initiates the conversion from an innocuous phase of high solubility and functionality...

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Detalles Bibliográficos
Autores principales: Ambadipudi, Susmitha, Biernat, Jacek, Riedel, Dietmar, Mandelkow, Eckhard, Zweckstetter, Markus
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5561136/
https://www.ncbi.nlm.nih.gov/pubmed/28819146
http://dx.doi.org/10.1038/s41467-017-00480-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5561136/
https://www.ncbi.nlm.nih.gov/pubmed/28819146
http://dx.doi.org/10.1038/s41467-017-00480-0

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