Periostin-binding DNA aptamer treatment attenuates renal fibrosis under diabetic conditions

Diabetic nephropathy, the major cause of chronic kidney disease, is associated with progressive renal fibrosis. Recently, accumulation of periostin, an extracellular matrix protein, was shown to augment renal fibrosis. Aptamers have higher binding affinities without developing the common side effect...

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Detalles Bibliográficos
Autores principales: Um, Jae Eun, Park, Jung Tak, Nam, Bo Young, Lee, Jung Pyo, Jung, Jong Ha, Kim, Youndong, Kim, Seonghun, Park, Jimin, Wu, Meiyan, Han, Seung Hyeok, Yoo, Tae-Hyun, Kang, Shin-Wook
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5561139/
https://www.ncbi.nlm.nih.gov/pubmed/28819200
http://dx.doi.org/10.1038/s41598-017-09238-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5561139/
https://www.ncbi.nlm.nih.gov/pubmed/28819200
http://dx.doi.org/10.1038/s41598-017-09238-6

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