Decoding disease-causing mechanisms of missense mutations from supramolecular structures

The inheritance modes of pathogenic missense mutations are known to be highly associated with protein structures; recessive mutations are mainly observed in the buried region of protein structures, whereas dominant mutations are significantly enriched in the interfaces of molecular interactions. How...

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Detalles Bibliográficos
Autores principales: Hijikata, Atsushi, Tsuji, Toshiyuki, Shionyu, Masafumi, Shirai, Tsuyoshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5561164/
https://www.ncbi.nlm.nih.gov/pubmed/28819267
http://dx.doi.org/10.1038/s41598-017-08902-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5561164/
https://www.ncbi.nlm.nih.gov/pubmed/28819267
http://dx.doi.org/10.1038/s41598-017-08902-1

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