Cooperative interaction of BMP signalling and Foxn1 gene dosage determines the size of the functionally active thymic epithelial compartment

Thymopoiesis strictly depends on the function of the Foxn1 transcription factor that is expressed in the thymic epithelium. During embryonic development, initial expression of the Foxn1 gene is induced in the pharyngeal endoderm by mesenchyme-derived BMP4 signals. Here, by engineering a time-delayed...

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Detalles Bibliográficos
Autores principales: Swann, Jeremy B., Krauth, Brigitte, Happe, Christiane, Boehm, Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5561201/
https://www.ncbi.nlm.nih.gov/pubmed/28819138
http://dx.doi.org/10.1038/s41598-017-09213-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5561201/
https://www.ncbi.nlm.nih.gov/pubmed/28819138
http://dx.doi.org/10.1038/s41598-017-09213-1

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