Shared peptide binding of HLA Class I and II alleles associate with cutaneous nevirapine hypersensitivity and identify novel risk alleles

Genes of the human leukocyte antigen (HLA) system encode cell-surface proteins involved in regulation of immune responses, and the way drugs interact with the HLA peptide binding groove is important in the immunopathogenesis of T-cell mediated drug hypersensitivity syndromes. Nevirapine (NVP), is an...

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Detalles Bibliográficos
Autores principales: Pavlos, Rebecca, McKinnon, Elizabeth J., Ostrov, David A., Peters, Bjoern, Buus, Soren, Koelle, David, Chopra, Abha, Schutte, Ryan, Rive, Craig, Redwood, Alec, Restrepo, Susana, Bracey, Austin, Kaever, Thomas, Myers, Paisley, Speers, Ellen, Malaker, Stacy A., Shabanowitz, Jeffrey, Jing, Yuan, Gaudieri, Silvana, Hunt, Donald F., Carrington, Mary, Haas, David W., Mallal, Simon, Phillips, Elizabeth J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5561238/
https://www.ncbi.nlm.nih.gov/pubmed/28819312
http://dx.doi.org/10.1038/s41598-017-08876-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5561238/
https://www.ncbi.nlm.nih.gov/pubmed/28819312
http://dx.doi.org/10.1038/s41598-017-08876-0

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