Cargando…

Linker histone H1 prevents R-loop accumulation and genome instability in heterochromatin

Linker histone H1 is an important structural component of chromatin that stabilizes the nucleosome and compacts the nucleofilament into higher-order structures. The biology of histone H1 remains, however, poorly understood. Here we show that Drosophila histone H1 (dH1) prevents genome instability as...

Descripción completa

Detalles Bibliográficos
Autores principales:	Bayona-Feliu, Aleix, Casas-Lamesa, Anna, Reina, Oscar, Bernués, Jordi, Azorín, Fernando
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5561251/ https://www.ncbi.nlm.nih.gov/pubmed/28819201 http://dx.doi.org/10.1038/s41467-017-00338-5

Ejemplares similares

Drosophila melanogaster linker histone dH1 is required for transposon silencing and to preserve genome integrity
por: Vujatovic, Olivera, et al.
Publicado: (2012)

Lysine 27 dimethylation of Drosophila linker histone dH1 contributes to heterochromatin organization independently of H3K9 methylation
por: Bernués, Jordi, et al.
Publicado: (2022)

The embryonic linker histone dBigH1 alters the functional state of active chromatin
por: Climent-Cantó, Paula, et al.
Publicado: (2020)

The histone variant H2A.W and linker histone H1 co-regulate heterochromatin accessibility and DNA methylation
por: Bourguet, Pierre, et al.
Publicado: (2021)

Drosophila linker histone H1 coordinates STAT-dependent organization of heterochromatin and suppresses tumorigenesis caused by hyperactive JAK-STAT signaling
por: Xu, Na, et al.
Publicado: (2014)

TDP-43 mutations link Amyotrophic Lateral Sclerosis with R-loop homeostasis and R loop-mediated DNA damage
por: Giannini, Marta, et al.
Publicado: (2020)

Methylation of histone H3 at lysine 23 in meiotic heterochromatin
por: Papazvan, Romeo, et al.
Publicado: (2013)

Linker Histone in Diseases
por: Ye, Xin, et al.
Publicado: (2017)

Loss of linker histone H1 in cellular senescence
por: Funayama, Ryo, et al.
Publicado: (2006)

Spatial heterogeneity of dynamics of H1 linker histone
por: Bernas, T., et al.
Publicado: (2014)

The tumour suppressor brain tumour (Brat) regulates linker histone dBigH1 expression in the Drosophila female germline and the early embryo
por: Climent-Cantó, Paula, et al.
Publicado: (2021)

Molecular and Cellular Functions of the Linker Histone H1.2
por: Lai, Shuting, et al.
Publicado: (2022)

Novel nucleosomal particles containing core histones and linker DNA but no histone H1
por: Cole, Hope A., et al.
Publicado: (2016)

Histone hypoacetylation is required to maintain late replication timing of constitutive heterochromatin
por: Casas-Delucchi, Corella S., et al.
Publicado: (2012)

Regulated nuclear accumulation of a histone methyltransferase times the onset of heterochromatin formation in C. elegans embryos
por: Mutlu, Beste, et al.
Publicado: (2018)

Eviction of linker histone H1 by NAP-family histone chaperones enhances activated transcription
por: Zhang, Qian, et al.
Publicado: (2015)

Dynamic Distribution of Linker Histone H1.5 in Cellular Differentiation
por: Li, Jing-Yu, et al.
Publicado: (2012)

Nuclear and nucleolar activity of linker histone variant H1.0
por: Kowalski, Andrzej
Publicado: (2016)

Linker histone H1.5 is an underestimated factor in differentiation and carcinogenesis
por: Behrends, Marthe, et al.
Publicado: (2020)

Linker histone H1 modulates defense priming and immunity in plants
por: Sheikh, Arsheed H, et al.
Publicado: (2023)

The Oocyte-Specific Linker Histone H1FOO Is Not Essential for Mouse Oogenesis and Fertility
por: Sánchez-Sáez, Fernando, et al.
Publicado: (2022)

Saccharomyces cerevisiae Linker Histone—Hho1p Maintains Chromatin Loop Organization during Ageing
por: Uzunova, Katya, et al.
Publicado: (2013)

Histone H3 lysine 4 methyltransferase is required for facultative heterochromatin at specific loci
por: Zhu, Qiaoqiao, et al.
Publicado: (2019)

Histone H3.3 phosphorylation promotes heterochromatin formation by inhibiting H3K9/K36 histone demethylase
por: Udugama, Maheshi, et al.
Publicado: (2022)

The histone chaperone FACT facilitates heterochromatin spreading by regulating histone turnover and H3K9 methylation states
por: Murawska, Magdalena, et al.
Publicado: (2021)

Histone deacetylation promotes transcriptional silencing at facultative heterochromatin
por: Watts, Beth R, et al.
Publicado: (2018)

H1.0 Linker Histone as an Epigenetic Regulator of Cell Proliferation and Differentiation
por: Di Liegro, Carlo Maria, et al.
Publicado: (2018)

Site-specific ubiquitylation acts as a regulator of linker histone H1
por: Höllmüller, Eva, et al.
Publicado: (2021)

Correction to ‘linker histone H1 modulates defense priming and immunity in plants’
Publicado: (2023)

Linker histone H1.2 and H1.4 affect the neutrophil lineage determination
por: Sollberger, Gabriel, et al.
Publicado: (2020)

Histone H2A.Z cooperates with RNAi and heterochromatin factors to suppress antisense RNAs
por: Zofall, Martin, et al.
Publicado: (2009)

Histone H4 Lysine 12 Acetylation Regulates Telomeric Heterochromatin Plasticity in Saccharomyces cerevisiae
por: Zhou, Bo O., et al.
Publicado: (2011)

New players in heterochromatin silencing: histone variant H3.3 and the ATRX/DAXX chaperone
por: Voon, Hsiao P.J., et al.
Publicado: (2016)

On the structure and dynamics of the complex of the nucleosome and the linker histone
por: Pachov, Georgi V., et al.
Publicado: (2011)

A histone H3K9M mutation traps histone methyltransferase Clr4 to prevent heterochromatin spreading
por: Shan, Chun-Min, et al.
Publicado: (2016)

Identification of replication-dependent and replication-independent linker histone complexes: Tpr specifically promotes replication-dependent linker histone stability
por: Zhang, Pei, et al.
Publicado: (2016)

UAP56/DDX39B is a major cotranscriptional RNA–DNA helicase that unwinds harmful R loops genome-wide
por: Pérez-Calero, Carmen, et al.
Publicado: (2020)

Fine Mapping of Posttranslational Modifications of the Linker Histone H1 from Drosophila melanogaster
por: Villar-Garea, Ana, et al.
Publicado: (2008)

Linker histone H1.0 interacts with an extensive network of proteins found in the nucleolus
por: Kalashnikova, Anna A., et al.
Publicado: (2013)

High-Resolution Mapping of H1 Linker Histone Variants in Embryonic Stem Cells
por: Cao, Kaixiang, et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_avkd2ln96m5lgdum9c71a3nmpr