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miR-16 and miR-125b are involved in barrier function dysregulation through the modulation of claudin-2 and cingulin expression in the jejunum in IBS with diarrhoea
OBJECTIVE: Micro-RNAs (miRNAs) play a crucial role in controlling intestinal epithelial barrier function partly by modulating the expression of tight junction (TJ) proteins. We have previously shown differential messenger RNA (mRNA) expression correlated with ultrastructural abnormalities of the epi...
Autores principales: | Martínez, Cristina, Rodiño-Janeiro, Bruno K, Lobo, Beatriz, Stanifer, Megan L, Klaus, Bernd, Granzow, Martin, González-Castro, Ana M, Salvo-Romero, Eloisa, Alonso-Cotoner, Carmen, Pigrau, Marc, Roeth, Ralph, Rappold, Gudrun, Huber, Wolfgang, González-Silos, Rosa, Lorenzo, Justo, de Torres, Inés, Azpiroz, Fernando, Boulant, Steeve, Vicario, María, Niesler, Beate, Santos, Javier |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BMJ Publishing Group
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5561373/ https://www.ncbi.nlm.nih.gov/pubmed/28082316 http://dx.doi.org/10.1136/gutjnl-2016-311477 |
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