Synthesis of a Bicyclic Azetidine with In Vivo Antimalarial Activity Enabled by Stereospecific, Directed C(sp(3))–H Arylation

[Image: see text] The development of new antimalarial therapeutics is necessary to address the increasing resistance to current drugs. Bicyclic azetidines targeting Plasmodium falciparum phenylalanyl-tRNA synthetase comprise one promising new class of antimalarials, especially due to their activitie...

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Detalles Bibliográficos
Autores principales: Maetani, Micah, Zoller, Jochen, Melillo, Bruno, Verho, Oscar, Kato, Nobutaka, Pu, Jun, Comer, Eamon, Schreiber, Stuart L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2017
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5561537/
https://www.ncbi.nlm.nih.gov/pubmed/28732448
http://dx.doi.org/10.1021/jacs.7b06994

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5561537/
https://www.ncbi.nlm.nih.gov/pubmed/28732448
http://dx.doi.org/10.1021/jacs.7b06994

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