Cargando…

SRSF1 promotes vascular smooth muscle cell proliferation through a Δ133p53/EGR1/KLF5 pathway

Though vascular smooth muscle cell (VSMC) proliferation underlies all cardiovascular hyperplastic disorders, our understanding of the molecular mechanisms responsible for this cellular process is still incomplete. Here we report that SRSF1 (serine/arginine-rich splicing factor 1), an essential splic...

Descripción completa

Detalles Bibliográficos
Autores principales:	Xie, Ning, Chen, Min, Dai, Rilei, Zhang, Yan, Zhao, Hanqing, Song, Zhiming, Zhang, Lufeng, Li, Zhenyan, Feng, Yuanqing, Gao, Hua, Wang, Li, Zhang, Ting, Xiao, Rui-Ping, Wu, Jianxin, Cao, Chun-Mei
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5561544/ https://www.ncbi.nlm.nih.gov/pubmed/28799539 http://dx.doi.org/10.1038/ncomms16016

Ejemplares similares

Δ113p53/Δ133p53: survival and integrity
por: Chen, Jun, et al.
Publicado: (2015)

EGR1 and KLF4 as Diagnostic Markers for Abdominal Aortic Aneurysm and Associated With Immune Infiltration
por: Guo, Chunguang, et al.
Publicado: (2022)

The Δ133p53 Isoforms, Tuners of the p53 Pathway
por: Joruiz, Sebastien M., et al.
Publicado: (2020)

An Egr-1-specific DNAzyme regulates Egr-1 and proliferating cell nuclear antigen expression in rat vascular smooth muscle cells
por: ZHANG, JUNBIAO, et al.
Publicado: (2013)

The RNA helicase p68 modulates expression and function of the Δ133 isoform(s) of p53, and is inversely associated with Δ133p53 expression in breast cancer
por: Moore, Hayley C, et al.
Publicado: (2010)

Egr2-independent, Klf1-mediated induction of PD-L1 in CD4(+) T cells
por: Teruya, Shuzo, et al.
Publicado: (2018)

ERK1/2-EGR1-SRSF10 Axis Mediated Alternative Splicing Plays a Critical Role in Head and Neck Cancer
por: Yadav, Sandhya, et al.
Publicado: (2021)

Δ133p53/FLp53 Predicts Poor Clinical Outcome in Esophageal Squamous Cell Carcinoma
por: Tu, Qimin, et al.
Publicado: (2020)

Regulation of Mcl-1 by SRSF1 and SRSF5 in Cancer Cells
por: Gautrey, Hannah L., et al.
Publicado: (2012)

p73 coordinates with Δ133p53 to promote DNA double-strand break repair
por: Gong, Hongjian, et al.
Publicado: (2018)

The p53 Isoform Δ133p53β Promotes Cancer Stem Cell Potential
por: Arsic, Nikola, et al.
Publicado: (2015)

TP53 drives invasion through expression of its Δ133p53β variant
por: Gadea, Gilles, et al.
Publicado: (2016)

Δ122p53, a mouse model of Δ133p53α, enhances the tumor-suppressor activities of an attenuated p53 mutant
por: Slatter, T L, et al.
Publicado: (2015)

Increased Expression of the Δ133p53β Isoform Enhances Brain Metastasis
por: Jesus, Alexandra N. Boix De, et al.
Publicado: (2023)

Δ133p53 is an independent prognostic marker in p53 mutant advanced serous ovarian cancer
por: Hofstetter, G, et al.
Publicado: (2011)

SRSF1-mediated alternative splicing is required for spermatogenesis
por: Lei, Wen-Long, et al.
Publicado: (2023)

Platelet-Derived Growth Factor Induces Rad Expression through Egr-1 in Vascular Smooth Muscle Cells
por: Luo, Yan, et al.
Publicado: (2011)

Elevation of the TP53 isoform Δ133p53β in glioblastomas: an alternative to mutant p53 in promoting tumor development
por: Kazantseva, Marina, et al.
Publicado: (2018)

Intronic TP53 Polymorphisms Are Associated with Increased Δ133TP53 Transcript, Immune Infiltration and Cancer Risk
por: Eiholzer, Ramona A., et al.
Publicado: (2020)

ΔNp73, TAp73 and Δ133p53 Extracellular Vesicle Cargo as Early Diagnosis Markers in Colorectal Cancer
por: Rodríguez-Cobos, Javier, et al.
Publicado: (2021)

Egr-1 mediates leptin-induced PPARγ reduction and proliferation of pulmonary artery smooth muscle cells
por: Xie, Xinming, et al.
Publicado: (2018)

The Δ133p53β isoform promotes an immunosuppressive environment leading to aggressive prostate cancer
por: Kazantseva, Marina, et al.
Publicado: (2019)

Role of Δ133p53 isoform in NF-κB inhibitor PDTC-mediated growth inhibition of MKN45 gastric cancer cells
por: Zhang, Hong-Mei, et al.
Publicado: (2017)

Egr1 mediates retinal vascular dysfunction in diabetes mellitus via promoting p53 transcription
por: Ao, Haocheng, et al.
Publicado: (2019)

The Role of egr1 in Early Zebrafish Retinogenesis
por: Zhang, Liyun, et al.
Publicado: (2013)

Increased Δ133p53 mRNA in lung carcinoma corresponds with reduction of p21 expression
por: Fragou, Aikaterini, et al.
Publicado: (2017)

Δ133p53α, a natural p53 isoform, contributes to conditional reprogramming and long-term proliferation of primary epithelial cells
por: Mondal, Abdul M., et al.
Publicado: (2018)

Activated CD90/Thy-1 fibroblasts co-express the Δ133p53β isoform and are associated with highly inflamed rheumatoid arthritis
por: Wiles, Anna K., et al.
Publicado: (2023)

Evaluation of EGR1 as a candidate gene for high myopia
por: Li, Tuo, et al.
Publicado: (2008)

Expression and prognostic value of the transcription factors EGR1 and EGR3 in gliomas
por: Knudsen, Arnon Møldrup, et al.
Publicado: (2020)

p53 isoform Δ133p53 promotes efficiency of induced pluripotent stem cells and ensures genomic integrity during reprogramming
por: Gong, Lu, et al.
Publicado: (2016)

The Δ133p53 Isoform Reduces Wtp53-induced Stimulation of DNA Pol γ Activity in the Presence and Absence of D4T
por: Liu, Kai, et al.
Publicado: (2017)

Egr-1 regulates the transcription of NGX6 gene through a Sp1/Egr-1 overlapping site in the promoter
por: Liu, Minji, et al.
Publicado: (2014)

Gfi1-Mediated Repression of c-Fos, Egr-1 and Egr-2, and Inhibition of ERK1/2 Signaling Contribute to the Role of Gfi1 in Granulopoiesis
por: Zhang, Yangyang, et al.
Publicado: (2019)

SRSF1 inhibition of HIV-1 gene expression
por: Paz, Sean, et al.
Publicado: (2015)

Genipin Inhibits TNF-α-Induced Vascular Smooth Muscle Cell Proliferation and Migration via Induction of HO-1
por: Jiang, Fengrong, et al.
Publicado: (2013)

Bioinformatics analysis of SRSF1-controlled gene networks in colorectal cancer
por: Sheng, Junxiu, et al.
Publicado: (2017)

Phosphorylation of SRSF1 is modulated by replicational stress
por: Leva, Valentina, et al.
Publicado: (2012)

Inhibition of Egr1 expression underlies the anti-mitogenic effects of cAMP in vascular smooth muscle cells
por: Kimura, Tomomi E., et al.
Publicado: (2014)

LncRNA KASRT Serves as a Potential Treatment Target by Regulating SRSF1-Related KLF6 Alternative Splicing and the P21/CCND1 Pathway in Osteosarcoma: An In Vitro and In Vivo Study
por: Chen, Kai, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_k3mfc52nuhel0m9ce6khsq5mdh