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Osteopontin deficiency protects mice from cholesterol gallstone formation by reducing expression of intestinal NPC1L1
Homeostasis of cholesterol is regulated by absorption in the intestine and synthesis in the liver. The authors previously demonstrated that OPN (osteopontin) exhibits the ability to alter hepatic cholesterol metabolism, thus affecting cholesterol gallstone formation in mice. The present study invest...
Autores principales: | Lin, Jing, Shao, Wei-Qing, Chen, Qing-Zhi, Zhu, Wen-Wei, Lu, Lu, Jia, Hu-Liang, Chen, Jin-Hong |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
D.A. Spandidos
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5561929/ https://www.ncbi.nlm.nih.gov/pubmed/28627641 http://dx.doi.org/10.3892/mmr.2017.6774 |
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