Defining the Structural Basis for Allosteric Product Release from E. coli Dihydrofolate Reductase Using NMR Relaxation Dispersion

[Image: see text] The rate-determining step in the catalytic cycle of E. coli dihydrofolate reductase is tetrahydrofolate (THF) product release, which can occur via an allosteric or an intrinsic pathway. The allosteric pathway, which becomes accessible when the reduced cofactor NADPH is bound, invol...

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Detalles Bibliográficos
Autores principales: Oyen, David, Fenwick, R. Bryn, Aoto, Phillip C., Stanfield, Robyn L., Wilson, Ian A., Dyson, H. Jane, Wright, Peter E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2017
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5562155/
https://www.ncbi.nlm.nih.gov/pubmed/28737940
http://dx.doi.org/10.1021/jacs.7b05958

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5562155/
https://www.ncbi.nlm.nih.gov/pubmed/28737940
http://dx.doi.org/10.1021/jacs.7b05958

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