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Defining the Structural Basis for Allosteric Product Release from E. coli Dihydrofolate Reductase Using NMR Relaxation Dispersion
[Image: see text] The rate-determining step in the catalytic cycle of E. coli dihydrofolate reductase is tetrahydrofolate (THF) product release, which can occur via an allosteric or an intrinsic pathway. The allosteric pathway, which becomes accessible when the reduced cofactor NADPH is bound, invol...
Autores principales: | Oyen, David, Fenwick, R. Bryn, Aoto, Phillip C., Stanfield, Robyn L., Wilson, Ian A., Dyson, H. Jane, Wright, Peter E. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Chemical
Society
2017
|
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5562155/ https://www.ncbi.nlm.nih.gov/pubmed/28737940 http://dx.doi.org/10.1021/jacs.7b05958 |
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