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Cathepsin K knockout protects against cardiac dysfunction in diabetic mice

Diabetes is a major risk factor for cardiovascular disease and the lysosomal cysteine protease cathepsin K plays a critical role in cardiac pathophysiology. To expand upon our previous findings, we tested the hypothesis that, knockout of cathepsin K protects against diabetes-associated cardiac anoma...

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Detalles Bibliográficos
Autores principales: Guo, Rui, Hua, Yinan, Rogers, Olivia, Brown, Travis E., Ren, Jun, Nair, Sreejayan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5562704/
https://www.ncbi.nlm.nih.gov/pubmed/28821796
http://dx.doi.org/10.1038/s41598-017-09037-z