Selective inhibition mechanism of RVX-208 to the second bromodomain of bromo and extraterminal proteins: insight from microsecond molecular dynamics simulations

RVX-208 is a recently reported inhibitor of bromo and extraterminal (BET) family proteins (including BRD2-4 and BRDT) with selectivity for the second bromodomain (BD2), currently in phase III clinical trials. Despite of its promising antitumor activity, due to the conserved folds of the first and se...

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Detalles Bibliográficos
Autores principales: Wang, Qianqian, Li, Ying, Xu, Jiahui, Wang, Yuwei, Leung, Elaine Lai-Han, Liu, Liang, Yao, Xiaojun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5562737/
https://www.ncbi.nlm.nih.gov/pubmed/28821780
http://dx.doi.org/10.1038/s41598-017-08909-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5562737/
https://www.ncbi.nlm.nih.gov/pubmed/28821780
http://dx.doi.org/10.1038/s41598-017-08909-8

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