Epac1-deficient mice have bleeding phenotype and thrombocytes with decreased GPIbβ expression

Epac1 (Exchange protein directly activated by cAMP 1) limits fluid loss from the circulation by tightening the endothelial barrier. We show here that Epac1(−/−) mice, but not Epac2(−/−) mice, have prolonged bleeding time, suggesting that Epac1 may limit fluid loss also by restraining bleeding. The E...

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Detalles Bibliográficos
Autores principales: Nygaard, Gyrid, Herfindal, Lars, Asrud, Kathrine S., Bjørnstad, Ronja, Kopperud, Reidun K., Oveland, Eystein, Berven, Frode S., Myhren, Lene, Hoivik, Erling A., Lunde, Turid Helen Felli, Bakke, Marit, Døskeland, Stein O., Selheim, Frode
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5562764/
https://www.ncbi.nlm.nih.gov/pubmed/28821815
http://dx.doi.org/10.1038/s41598-017-08975-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5562764/
https://www.ncbi.nlm.nih.gov/pubmed/28821815
http://dx.doi.org/10.1038/s41598-017-08975-y

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