TRPM6 and TRPM7 differentially contribute to the relief of heteromeric TRPM6/7 channels from inhibition by cytosolic Mg(2+) and Mg·ATP

TRPM6 and its homologue TRPM7 are α-kinase-coupled divalent cation-selective channels activated upon reduction of cytosolic levels of Mg(2+) and Mg·ATP. TRPM6 is vital for organismal Mg(2+) balance. However, mechanistically the cellular role and functional nonredundancy of TRPM6 remain incompletely...

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Detalles Bibliográficos
Autores principales: Ferioli, Silvia, Zierler, Susanna, Zaißerer, Joanna, Schredelseker, Johann, Gudermann, Thomas, Chubanov, Vladimir
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5562840/
https://www.ncbi.nlm.nih.gov/pubmed/28821869
http://dx.doi.org/10.1038/s41598-017-08144-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5562840/
https://www.ncbi.nlm.nih.gov/pubmed/28821869
http://dx.doi.org/10.1038/s41598-017-08144-1

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