A reversible phospho-switch mediated by ULK1 regulates the activity of autophagy protease ATG4B

Upon induction of autophagy, the ubiquitin-like protein LC3 is conjugated to phosphatidylethanolamine (PE) on the inner and outer membrane of autophagosomes to allow cargo selection and autophagosome formation. LC3 undergoes two processing steps, the proteolytic cleavage of pro-LC3 and the de-lipida...

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Detalles Bibliográficos
Autores principales: Pengo, N., Agrotis, A., Prak, K., Jones, J., Ketteler, R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5562857/
https://www.ncbi.nlm.nih.gov/pubmed/28821708
http://dx.doi.org/10.1038/s41467-017-00303-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5562857/
https://www.ncbi.nlm.nih.gov/pubmed/28821708
http://dx.doi.org/10.1038/s41467-017-00303-2

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