Cargando…

Genetic deletion of mGlu2 metabotropic glutamate receptors improves the short-term outcome of cerebral transient focal ischemia

We have recently shown that pharmacological blockade of mGlu2 metabotropic glutamate receptors protects vulnerable neurons in the 4-vessel occlusion model of transient global ischemia, whereas receptor activation amplifies neuronal death. This raised the possibility that endogenous activation of mGl...

Descripción completa

Detalles Bibliográficos
Autores principales:	Mastroiacovo, Federica, Moyanova, Slavianka, Cannella, Milena, Gaglione, Anderson, Verhaeghe, Remy, Bozza, Giovanna, Madonna, Michele, Motolese, Marta, Traficante, Anna, Riozzi, Barbara, Bruno, Valeria, Battaglia, Giuseppe, Lodge, David, Nicoletti, Ferdinando
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2017
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5562974/ https://www.ncbi.nlm.nih.gov/pubmed/28821279 http://dx.doi.org/10.1186/s13041-017-0319-6

Ejemplares similares

mGlu2 metabotropic glutamate receptors restrain inflammatory pain and mediate the analgesic activity of dual mGlu2/mGlu3 receptor agonists
por: Zammataro, Magda, et al.
Publicado: (2011)

Targeting type-2 metabotropic glutamate receptors to protect vulnerable hippocampal neurons against ischemic damage
por: Motolese, Marta, et al.
Publicado: (2015)

Genetic Deletion of mGlu3 Metabotropic Glutamate Receptors Amplifies Ischemic Brain Damage and Associated Neuroinflammation in Mice
por: Mastroiacovo, Federica, et al.
Publicado: (2021)

mGlu1 Receptors Monopolize the Synaptic Control of Cerebellar Purkinje Cells by Epigenetically Down-Regulating mGlu5 Receptors
por: Notartomaso, Serena, et al.
Publicado: (2018)

Developmental up-regulation of NMDA receptors in the prefrontal cortex and hippocampus of mGlu5 receptor knock-out mice
por: Imbriglio, Tiziana, et al.
Publicado: (2021)

mGlu3 Metabotropic Glutamate Receptors as a Target for the Treatment of Absence Epilepsy: Preclinical and Human Genetics Data
por: Celli, Roberta, et al.
Publicado: (2023)

Correction to: Developmental up-regulation of NMDA receptors in the prefrontal cortex and hippocampus of mGlu5 receptor knock-out mice
por: Imbriglio, Tiziana, et al.
Publicado: (2021)

Targeting mGlu5 Metabotropic Glutamate Receptors in the Treatment of Cognitive Dysfunction in a Mouse Model of Phenylketonuria
por: Nardecchia, Francesca, et al.
Publicado: (2018)

Pharmacological enhancement of mGlu1 metabotropic glutamate receptors causes a prolonged symptomatic benefit in a mouse model of spinocerebellar ataxia type 1
por: Notartomaso, Serena, et al.
Publicado: (2013)

Place field stability requires the metabotropic glutamate receptor, mGlu5
por: Zhang, Sijie, et al.
Publicado: (2014)

Decreased striatal dopamine in group II metabotropic glutamate receptor (mGlu2/mGlu3) double knockout mice
por: Lane, Tracy A, et al.
Publicado: (2013)

Xanthurenic Acid Activates mGlu2/3 Metabotropic Glutamate Receptors and is a Potential Trait Marker for Schizophrenia
por: Fazio, Francesco, et al.
Publicado: (2015)

An Appraisal of the Influence of the Metabotropic Glutamate 5 (mGlu5) Receptor on Sociability and Anxiety
por: Ramos-Prats, Arnau, et al.
Publicado: (2019)

Phosphorylation and regulation of group II metabotropic glutamate receptors (mGlu2/3) in neurons
por: Mao, Li-Min, et al.
Publicado: (2022)

N-Acetyl-cysteine causes analgesia by reinforcing the endogenous activation of type-2 metabotropic glutamate receptors
por: Bernabucci, Matteo, et al.
Publicado: (2012)

Activation of mGlu3 Receptors Stimulates the Production of GDNF in Striatal Neurons
por: Battaglia, Giuseppe, et al.
Publicado: (2009)

Tetrahydronaphthyridine and Dihydronaphthyridinone Ethers As Positive Allosteric Modulators of the Metabotropic Glutamate Receptor 5 (mGlu(5))
por: Turlington, Mark, et al.
Publicado: (2014)

Altered Short-Term Synaptic Plasticity in Mice Lacking the Metabotropic Glutamate Receptor mGlu7
por: Bushell, Trevor J., et al.
Publicado: (2002)

Protein Networks Associated with Native Metabotropic Glutamate 1 Receptors (mGlu(1)) in the Mouse Cerebellum
por: Mansouri, Mahnaz, et al.
Publicado: (2023)

The Metabotropic Glutamate Receptor, mGlu5, Is Required for Extinction Learning That Occurs in the Absence of a Context Change
por: André, Marion Agnes Emma, et al.
Publicado: (2015)

Glutamate Metabotropic Receptor Type 3 (mGlu3) Localization in the Rat Prelimbic Medial Prefrontal Cortex
por: Woo, Elizabeth, et al.
Publicado: (2022)

Abnormal Hippocampal Melatoninergic System: A Potential Link between Absence Epilepsy and Depression-Like Behavior in WAG/Rij Rats?
por: Moyanova, Slavianka, et al.
Publicado: (2018)

Deletion of Metabotropic Glutamate Receptors 2 and 3 (mGlu2 & mGlu3) in Mice Disrupts Sleep and Wheel-Running Activity, and Increases the Sensitivity of the Circadian System to Light
por: Pritchett, David, et al.
Publicado: (2015)

A group II metabotropic glutamate receptor 3 (mGlu3, GRM3) isoform implicated in schizophrenia interacts with canonical mGlu3 and reduces ligand binding
por: García-Bea, Aintzane, et al.
Publicado: (2017)

Targeting mGlu Receptors for Optimization of Antipsychotic Activity and Disease-Modifying Effect in Schizophrenia
por: Nicoletti, Ferdinando, et al.
Publicado: (2019)

Structural insights into dimerization and activation of the mGlu2–mGlu3 and mGlu2–mGlu4 heterodimers
por: Wang, Xinwei, et al.
Publicado: (2023)

Could MDMA Promote Stemness Characteristics in Mouse Embryonic Stem Cells via mGlu5 Metabotropic Glutamate Receptors?
por: Meamar, Rokhsareh, et al.
Publicado: (2012)

Fractionation of Spatial Memory in GRM2/3 (mGlu2/mGlu3) Double Knockout Mice Reveals a Role for Group II Metabotropic Glutamate Receptors at the Interface Between Arousal and Cognition
por: Lyon, Louisa, et al.
Publicado: (2011)

Radiosynthesis and Evaluation of an (18)F-Labeled Positron Emission Tomography (PET) Radioligand for Metabotropic Glutamate Receptor Subtype 4 (mGlu(4))
por: Kil, Kun-Eek, et al.
Publicado: (2014)

Metabotropic glutamate receptor 3 (mGlu3; mGluR3; GRM3) in schizophrenia: Antibody characterisation and a semi-quantitative western blot study
por: García-Bea, Aintzane, et al.
Publicado: (2016)

Age-dependence of sensorimotor and cerebral electroencephalographic asymmetry in rats subjected to unilateral cerebrovascular stroke
por: Moyanova, Slavianka G, et al.
Publicado: (2013)

43.1 GENETIC INSIGHTS LEAD TO DISCOVERY OF SELECTIVE ACTIVATORS OF MGLU1 AND MGLU3 METABOTROPIC GLUTAMATE RECEPTORS AS POTENTIAL TREATMENTS FOR SCHIZOPHRENIA
por: Conn, P Jeffrey, et al.
Publicado: (2018)

Perineuronal nets are under the control of type-5 metabotropic glutamate receptors in the developing somatosensory cortex
por: Mascio, Giada, et al.
Publicado: (2021)

mGlu3 receptor regulates microglial cell reactivity in neonatal rats
por: Zinni, Manuela, et al.
Publicado: (2021)

A large consanguineous family with a homozygous Metabotropic Glutamate Receptor 7 (mGlu7) variant and developmental epileptic encephalopathy: Effect on protein structure and ligand affinity
por: Jdila, Marwa Ben, et al.
Publicado: (2021)

Targeting mGlu1 Receptors in the Treatment of Motor and Cognitive Dysfunctions in Mice Modeling Type 1 Spinocerebellar Ataxia
por: Liberatore, Francesca, et al.
Publicado: (2022)

Allosteric Modulators for mGlu Receptors
por: Gasparini, F, et al.
Publicado: (2007)

Selective Blockade of the Metabotropic Glutamate Receptor mGluR5 Protects Mouse Livers in In Vitro and Ex Vivo Models of Ischemia Reperfusion Injury
por: Ferrigno, Andrea, et al.
Publicado: (2018)

Glial metabotropic glutamate receptor-4 increases maturation and survival of oligodendrocytes
por: Spampinato, Simona Federica, et al.
Publicado: (2015)

Optical control of pain in vivo with a photoactive mGlu(5) receptor negative allosteric modulator
por: Font, Joan, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_s92ormfc9ck946ifrd1pe3eso2