PIK3CA mutations in HER2-positive Breast Cancer Patients; Frequency and Clinicopathological Perspective in Egyptian Patients

Missense mutations in PIK3CA are common in breast cancers. They mostly involve exons 9 and 20 which encode kinase and helical domains of the protein and may result in its activation. PIK3CA activating mutations were previously shown to predict lower pathologic complete response (pCR) in HER2-positiv...

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Detalles Bibliográficos
Autores principales: Elwy, Fatma, Helwa, Reham, El Leithy, Asmaa A, El din, Zeinab Shehab, Assem, Magda M, Hassan, Nagwa H A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: West Asia Organization for Cancer Prevention 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5563120/
https://www.ncbi.nlm.nih.gov/pubmed/28240010
http://dx.doi.org/10.22034/APJCP.2017.18.1.57

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5563120/
https://www.ncbi.nlm.nih.gov/pubmed/28240010
http://dx.doi.org/10.22034/APJCP.2017.18.1.57

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