Purinergic signalling links mechanical breath profile and alveolar mechanics with the pro-inflammatory innate immune response causing ventilation-induced lung injury

Severe pulmonary infection or vigorous cyclic deformation of the alveolar epithelial type I (AT I) cells by mechanical ventilation leads to massive extracellular ATP release. High levels of extracellular ATP saturate the ATP hydrolysis enzymes CD39 and CD73 resulting in persistent high ATP levels de...

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Detalles Bibliográficos
Autores principales: Hasan, Djo, Blankman, Paul, Nieman, Gary F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Netherlands 2017
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5563293/
https://www.ncbi.nlm.nih.gov/pubmed/28547381
http://dx.doi.org/10.1007/s11302-017-9564-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5563293/
https://www.ncbi.nlm.nih.gov/pubmed/28547381
http://dx.doi.org/10.1007/s11302-017-9564-5

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