Quantitative Comparison of Effects of Dofetilide, Sotalol, Quinidine, and Verapamil between Human Ex vivo Trabeculae and In silico Ventricular Models Incorporating Inter-Individual Action Potential Variability

Background: In silico modeling could soon become a mainstream method of pro-arrhythmic risk assessment in drug development. However, a lack of human-specific data and appropriate modeling techniques has previously prevented quantitative comparison of drug effects between in silico models and recordi...

Descripción completa

Detalles Bibliográficos
Autores principales: Britton, Oliver J., Abi-Gerges, Najah, Page, Guy, Ghetti, Andre, Miller, Paul E., Rodriguez, Blanca
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2017
Materias:
Physiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5563361/
https://www.ncbi.nlm.nih.gov/pubmed/28868038
http://dx.doi.org/10.3389/fphys.2017.00597

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5563361/
https://www.ncbi.nlm.nih.gov/pubmed/28868038
http://dx.doi.org/10.3389/fphys.2017.00597

Ejemplares similares