Elucidation of Molecular Mechanisms of Streptozotocin-Induced Oxidative Stress, Apoptosis, and Mitochondrial Dysfunction in Rin-5F Pancreatic β-Cells

Streptozotocin is a pancreatic beta-cell-specific cytotoxin and is widely used to induce experimental type 1 diabetes in rodent models. The precise molecular mechanism of STZ cytotoxicity is however not clear. Studies have suggested that STZ is preferably absorbed by insulin-secreting β-cells and in...

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Detalles Bibliográficos
Autores principales: Nahdi, Arwa M. T. Al, John, Annie, Raza, Haider
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5563420/
https://www.ncbi.nlm.nih.gov/pubmed/28845214
http://dx.doi.org/10.1155/2017/7054272

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5563420/
https://www.ncbi.nlm.nih.gov/pubmed/28845214
http://dx.doi.org/10.1155/2017/7054272

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