Structures of carboxylic acid reductase reveal domain dynamics underlying catalysis

Carboxylic acid reductase (CAR) catalyzes the ATP- and NADPH-dependent reduction of carboxylic acids to the corresponding aldehydes. The enzyme is related to the non-ribosomal peptide synthetases, consisting of an adenylation domain fused via a peptidyl carrier protein (PCP) to a reductase terminati...

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Detalles Bibliográficos
Autores principales: Gahloth, Deepankar, Dunstan, Mark S., Quaglia, Daniela, Klumbys, Evaldas, Lockhart-Cairns, Michael P., Hill, Andrew M., Derrington, Sasha R., Scrutton, Nigel S., Turner, Nicholas J., Leys, David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5563451/
https://www.ncbi.nlm.nih.gov/pubmed/28719588
http://dx.doi.org/10.1038/nchembio.2434

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5563451/
https://www.ncbi.nlm.nih.gov/pubmed/28719588
http://dx.doi.org/10.1038/nchembio.2434

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