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Structures of carboxylic acid reductase reveal domain dynamics underlying catalysis

Carboxylic acid reductase (CAR) catalyzes the ATP- and NADPH-dependent reduction of carboxylic acids to the corresponding aldehydes. The enzyme is related to the non-ribosomal peptide synthetases, consisting of an adenylation domain fused via a peptidyl carrier protein (PCP) to a reductase terminati...

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Detalles Bibliográficos
Autores principales:	Gahloth, Deepankar, Dunstan, Mark S., Quaglia, Daniela, Klumbys, Evaldas, Lockhart-Cairns, Michael P., Hill, Andrew M., Derrington, Sasha R., Scrutton, Nigel S., Turner, Nicholas J., Leys, David
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5563451/ https://www.ncbi.nlm.nih.gov/pubmed/28719588 http://dx.doi.org/10.1038/nchembio.2434

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