Differential alternative splicing coupled to nonsense-mediated decay of mRNA ensures dietary restriction-induced longevity

Alternative splicing (AS) coupled to nonsense-mediated decay (AS-NMD) is a conserved mechanism for post-transcriptional gene regulation. Here we show that, during dietary restriction (DR), AS is enhanced in Caenorhabditis elegans and mice. A splicing mediator hrpu-1 regulates a significant part of t...

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Detalles Bibliográficos
Autores principales: Tabrez, Syed Shamsh, Sharma, Ravi Datta, Jain, Vaibhav, Siddiqui, Atif Ahmed, Mukhopadhyay, Arnab
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5563511/
https://www.ncbi.nlm.nih.gov/pubmed/28824175
http://dx.doi.org/10.1038/s41467-017-00370-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5563511/
https://www.ncbi.nlm.nih.gov/pubmed/28824175
http://dx.doi.org/10.1038/s41467-017-00370-5

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